Non-carrier-added Radiochemical for non-clinical research purposes
Non-carrier-added [177Lu]Lutetium Chloride solution for your research activities. The radiochemical solution is used for the preparation of radiolabeled compounds in the non-clinical research context.
Lutetium-177 (n.c.a) is currently only available in non-GMP research grade. Our teams are working on the provision of GMP grade [177Lu]Lutetium Chloride solution starting in Q3 2022. Use the contact form at the end of the page to get in touch and find out more.
Lutetium-177 is a β-emitter with a half-life of 6.65 days. It can be produced via two different routes, direct by irradiation of Lutetium-176 for carrier-added or indirect by irradiation of Ytterbium-176 for non-carrier-added form. Lutetium-177 decays by emission of beta radiation (β–: Emax= 498 keV) and gamma radiation (γ: 208 keV – 10.3 % abundance) to Hafnium-177.
Lutetium-177 has become more and more important over the last years as a substance used in many new radiopharmaceuticals, especially for cancer therapy. In combination with diagnostic [68Ga]-based-agents it is now the main therapeutic nuclide for theranostic approaches such as with DOTA-conjugated compounds for binding on the prostate specific membrane antigen (PSMA). A large number of further radiotherapeutic agents are currently under development for several types of cancer..
Method and specifications
Eckert & Ziegler offers Lutetium-177 in high quality no-carrier-added (n.c.a.) form. [177Lu]Lutetium Chloride Solution is produced by irradiation of [176Yb]Ytterbium and subsequent separation of [177Lu]Lutetium in our radiochemical facility. This process achieves highest purity.
|Product||[177Lu]Lutetium Chloride solution (clear and colorless)|
|Active Ingredient||[177Lu]Lutetium Chloride, 40 GBq/mL|
|Excipients||Hydrochloric Acid (0.04 M)|
|Chemical Form||[177Lu]LuCl3 in 0.04 M hydrochloric acid solution|
|Activity||as requested 4 – 200 GBq per vial* (activity tolerance ± 10%)|
|Radiochemical purity||> 99.0 % [177Lu]Lutetium as Lu3+|
|pH||1 – 2|
|Sterility||Sterile (from Q3 2022)|
*traceable to PTB and NIST
Shipping and calibration
Eckert & Ziegler offers high flexibility regarding calibration time and date. A pre-calibration up to seven days is possible.
Lutetium-177 will be delivered within four business days worldwide.
Since March 2020, Eckert & Ziegler is supplying [177Lu]Lutetium Chloride solution to selected customers for non-clinical research. We are continuously expanding our production to provide additional batches to further customers. Furthermore, we plan to have Lutetium-177 in GMP quality available in 2022.
Product specific questions?
Eckert & Ziegler