JUN 20
Nuclear Medicine

Illuminating Innovation – Q1/2023

There is a lot of fascinating work being done out there that involves our products.

So we sat down and compiled a list for you with recent open access publications out there, where radionuclides or lab devices from Eckert & Ziegler have been used.

This is the start of a quarterly series. If you would like to see your publication in a future iteration, make sure to contact us!

Two people working with a Galliapharm® with EluGen

Introduction to “Illuminating Innovation”

For decades, we have been providing radionuclides, radiopharmaceuticals, radiosynthesizers and QC equipment to international institutions. There is now a long list of clinics and research institutes all over the world working with our products. And time and time again these institutions publish extraordinary work.

To highlight their achievements, we compiled a list of publications from the first quarter of 2023, where one of our products was involved.

Mostly open access articles

Except for a select few publications, the list only includes open access articles. This is mainly due to the fact, that we can easily identify the involvement of our products in publications if access is not restricted. If you have published or are working on something with our products, make sure to contact us at marketing.medical@ezag.de, so we can add it or include it in a future edition, whether it be open access or not.

Enjoy reading through these interesting articles and see you next quarter!

Publications Q1 / 2023

The publications are categorized by their field of medical application and sorted by their online publishing date (descending).

CARDIOLOGY

[68Ga]Ga-NODAGA-E[(cRGDyK)]2 and [64Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy
Jan 11, 2023 | Follin B et al.
Modular-Lab PharmTracer and IGG100 used for the preparation of [68Ga]Ga-NODAGA-E[(cRGDyK)]2

 

ENDOCRINOLOGY

[18F]MK-7246 for Positron Emission Tomography Imaging of the Beta-Cell Surface Marker GPR44
Feb 02, 2023 | Cheung P et al.
Flow-count PMT detector used for semi-prep HPLC and radiochemical analysis of [18F]MK-7246

Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma
Jan 01, 2023 | Chen P et al.
Mini-Scan used for radiochemical analysis of [125I]iodine-labeled supramolecular nanofibers

 

GASTROENTOROLOGY

Radioimmune Imaging of α4β7 Integrin and TNFα for Diagnostic and Therapeutic Applications in Inflammatory Bowel Disease
Mar 2, 2023 | Signore A et al.
Mini-Scan used for radiochemical analysis of [99mTc]technetium-labeled anti-TNFα monoclonal antibodies

68Ga-cyc-DX600 PET/CT in ACE2-targeted tumor imaging
Feb 27, 2023 | Ren F et al.
Flow-count used for radiochemical analysis of [68Ga]Ga-cyc-DX600

Prospective Multicentric Assessment of 68Ga-DOTANOC PET/CT in Grade 1-2 GEP-NET
Jan 14, 2023 | Lugat A et al.
Modular-Lab PharmTracer and GalliaPharm® used for the preparation of [68Ga]Ga-DOTANOC

Radiochemical Synthesis of 4-[18F]FluorobenzylAzide and Its Conjugation with EGFR-Specific Aptamers
Dec 30, 2022 | Il‘in VA et al.
Modular-Lab PharmTracer used for the preparation of 4-[18F]fluorobenzylazide

 

HEMATOLOGY

Automated synthesis and quality control of [68Ga]Ga-PentixaFor using the Gaia/Luna Elysia-Raytest module for CXCR4 PET imaging
Feb 07, 2023 | Migliari S et al.
GalliaPharm® and PentixaFor precursor used for the preparation of [68Ga]Ga-PentixaFor

PET/CT of the Spleen with Gallium-Oxine-Labeled, Heat-Damaged Red Blood Cells: Clinical Experience and Technical Aspects
Feb 03, 2023 | Drescher R et al.
GalliaPharm® used for the preparation of [68Ga]Ga-oxine

 

HEPATOLOGY

Liver PET Reloaded: Automated Synthesis of [68Ga]Ga-BP-IDA for Positron Imaging of the Hepatobiliary Function and First Clinical Experience
Mar 16, 2023 | Werner A et al.
GalliaPharm® used for the preparation of [68Ga]Ga-BP-IDA

 

NEUROLOGY

Measurement of Aβ Amyloid Plaques and Tau Protein in Postmortem Human Alzheimer’s Disease Brain by Autoradiography Using [18F]Flotaza, [125I]IBETA, [124/125I]IPPI and Immunohistochemistry Analysis Using QuPath
Mar 27, 2023 | Mondal R et al.
AR-2000 used for analysis of [18F]Flotaza, [125I]IBETA, [125I]IPPI

Automated Synthesis of [18F]Flumazenil Application in GABAA Receptor Neuroimaging Availability for Rat Model of Anxiety
Mar 9, 2023 | Farn SS et al.
Flow-Count used for radiochemical analysis of [18F]Flumazenil

Abnormal [18F]NIFENE binding in transgenic 5xFAD mouse model of Alzheimer’s disease: In vivo PET/CT imaging studies of α4β2* nicotinic acetylcholinergic receptors and in vitro correlations with Aβ plaques
Feb 23, 2023 | Liang C et al.
AR-2000 used for radiochemical analysis of [18F]flourine- and [125I]iodine-labeled compounds

Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA receptors
Jan 27, 2023 (preprint) | Korff M et al.
AR-2000 used for radiochemical analysis of [18F]flouride-labeled compounds

Development of [124/125I]IAZA as a New Proteinopathy Imaging Agent for Alzheimer‘s Disease
Jan 15, 2023 | Reddy TT et al.
AR-2000 used for radiochemical analysis of [124/125I]IAZA

 

PNEUMOLOGY

Safety, Biodistribution, and Dosimetry Study of Meplazumab, a Potential COVID-19 Therapeutic Drug, with 131I-Labeling and SPECT Imaging
Jan 20, 2023 | Ye J et al.
Mini-Scan used for radiochemical analysis of [131I]iodine-labeled Meplazumab

 

UROLOGY

Improved quality control of [177Lu]Lu-PSMA I&T
Mar 27, 2023 | Kraihammer M et al.
Modular-Lab PharmTracer used for preparation of [177Lu]Lu-PSMA-I&T

Selective ablation of TRA-1-60+ pluripotent stem cells suppresses tumor growth of prostate cancer
Mar 27, 2023 | White JM et al.
Mini-Scan used for analysis of [89Zr]Zr-DFO-Bstrongomab and [177Lu]Lu-CHX-A”-DTPA-Bstrongomab

Comparison of Hormone-Sensitive Oligorecurrent Prostate Cancer Patients Based on Routine Use of Choline and/or PSMA PET/CT to Guide Metastasis-Directed Therapy
Mar 22, 2023 | Metz R et al.
Modular-Lab PharmTracer used for preparation of [68Ga]Ga-PSMA-HBEDCC

Multimodal Radiobioconjugates of Magnetic Nanoparticles Labeled with 44Sc and 47Sc for Theranostic Application
Mar 5, 2023 | Ünak P et al.
AR-2000 used for radiochemical analysis of [44Sc]scandium- and [47Sc]scandium-labeled compounds

Detection Efficacy of 68Ga-PSMA-11 PET/CT in Biochemical Recurrence of Prostate Cancer with Very Low PSA Levels: A 7-Year, Two-Center “Real-World” Experience
Feb 21, 2023 | Burgard C et al.
GalliaPharm® used for the preparation of [68Ga]Ga-PSMA-11

Baseline [68Ga]Ga-PSMA-11 PET/CT before [177Lu]Lu-PSMA-617 Radioligand Therapy: Value of PSMA-Uptake Thresholds in Predicting Targetable Lesions
Jan 12, 2023 | Groener D et al.
GalliaPharm® used for the preparation of [68Ga]Ga-PSMA-11

 

MULTIPLE APPLICATIONS

SPECT Imaging with Tc-99m-Labeled HYNIC-FAPI-04 to Extend the Differential Time Window in Evaluating Tumor Fibrosis
Mar 10, 2023 | Luo X et al.
Mini-Scan used for radiochemical analysis of [99mTc]Tc-HYNIC-FAPI-04

A novel molecular imaging probe [99mTc]Tc-HYNIC-FAPI targeting cancer-associated fibroblasts
Mar 6, 2023 | Jinag Y et al.
Mini-Scan used for radiochemical analysis of [99mTc]Tc-HYNIC-FAPI

Scandium-44 Radiolabeled Peptide and Peptidomimetic Conjugates Targeting Neuropilin-1 Co-Receptor as Potential Tools for Cancer Diagnosis and Anti-Angiogenic Therapy
Feb 15, 2023 | Maslowska K et al.
GalliaPharm® used for the preparation of [68Ga]Ga-DOTA-Ahx-A7R and [68Ga]Lys(hArg)-Dab(Ahx-DOTA-Ga)-Pro-Arg

Effects of Side Chain and Peptide Bond Modifications on the Targeting Properties of Stabilized Minigastrin Analogs
Feb 13, 2023 | Zavvar TS et al.
GalliaPharm® used for radiolabeling of a variety of DOTA-compounds with [68Ga]gallium

Towards Radiolabeled EGFR-Specific Peptides: Alternatives to GE11
Feb 11, 2023 | Judmann B et al.
GalliaPharm® used for radiolabeling of a variety of compounds with [68Ga]gallium

[99mTc]Technetium-Labeled Niosomes: Radiolabeling, Quality Control, and In Vitro Evaluation
Feb 08, 2023 | Ekinci M et al.
AR-2000 used for radiochemical analysis of [99mTc]technetium-labeled compounds

In Vivo Evaluation of a Gallium-68-Labeled Tumor-Tracking Cyanine Dye for Positron Emission Tomography/Near-Infrared Fluorescence Carcinoma Imaging, Image-Guided Surgery, and Photothermal Therapy
Feb 02, 2023 | Zhu J et al.
Flow-count used for radiochemical analysis of [68Ga]Ga-DOTA-IR808

Therapeutic Performance Evaluation of 213Bi-Labelled Aminopeptidase N (APN/CD13)-Affine NGR-Motif ([213Bi]Bi-DOTAGA-cKNGRE) in Experimental Tumour Model: A Treasured Tailor for Oncology
Feb 01, 2023 | Képes Z et al.
GalliaPharm® used for the preparation of [68Ga]Ga-DOTAGA-cKNGRE

Synthesis, Radiolabeling, and In Vitro and In Vivo Characterization of Heterobivalent Peptidic Agents for Bispecific EGFR and Integrin αvβ3 Targeting
Jan 04, 2023 | Braun D et al.
IGG100 used for preparation of [68Ga]NODAGA-PEG3-GE11-PEG3-c(RGDyK) and [68Ga]NODAGA-PEG5-GE11-PEG5-c(RGDfK)

 

OTHER

“Click-to-Clear”: A Strategy to Minimize Radioactivity from the Blood Pool Utilizing Staudinger Ligation
Feb 21, 2023 | Soni N et al.
Flow-Count used for radiodetection in [131I]iodine-labeled compounds

Radiolysis-Associated Decrease in Radiochemical Purity of 177Lu-Radiopharmaceuticals and Comparison of the Effectiveness of Selected Quenchers against This Process
Feb 16, 2023 | Larenkov A et al.
MiniScanPRO and Flow-count used for radiochemical analysis of [177Lu]Lu-PSMA-617

In Vitro Hemocompatibility and Genotoxicity Evaluation of Dual-Labeled [99mTc]Tc-FITC-Silk Fibroin Nanoparticles for Biomedical Applications
Feb 07, 2023 | Asensio Ruiz MA et al.
AR-2000 used for radiochemical analysis of [99mTc]Tc-FITC-SFN

Peptide-based positron emission tomography probes: current strategies for synthesis and radiolabelling
Jan 06, 2023 | Failla M et al.
Modular-Lab PharmTracer used for preparation of N-succinimidyl-4-[18F]fluorobenzoate

Want to see your publication here?

If you would like to add your publication to one of the future iterations of “Illuminating Innovation”, make sure to contact us at marketing.medical@ezag.de

Marius Wölfges
Marius Wölfges Junior Marketing Manager

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