Illuminating Innovation – Q2/2023

In the ever-evolving landscape of scientific research and healthcare, our commitment to innovation continues to shine. For years, we have been at the forefront, delivering radionuclides, radiopharmaceuticals, radiosynthesizers, and quality control equipment to institutions worldwide. Today, a growing network of clinics and research facilities around the globe entrusts our products for their groundbreaking work.

In this latest edition, we once again turn the spotlight on the remarkable accomplishments of these institutions. We’ve combed through the second quarter of 2023 to curate a fresh selection of publications where our products have played an integral role. Join us as we delve into these recent successes and the impact of our solutions in the field.

If you’ve missed out on the first one, make sure to check it out here!

The publications are categorized by their field of medical application and sorted by their online publishing date (descending).

CARDIOLOGY

⁶⁸Ga-labeled WVP peptide as a novel PET probe for molecular biological diagnosis of unstable thoracic aortic aneurysm and early dissection: an animal study
Jun 12, 2023 | Lu X et al. 
Flow-Count used for HPLC analysis of [⁶⁸Ga]Ga-DOTA-WVP

GASTROENTEROLOGY

New Radiolabeled Exendin Analogues Show Reduced Renal Retention
Jun 02, 2023 | Joosten L et al.
GalliaPharm^® used to radiolabel Exendin-4 analogues with [⁶⁸Ga]Gallium

HEMATOLOGY

Development of a New Class of CXCR4-Targeting Radioligands Based on the Endogenous Antagonist EPI-X4 for Oncological Applications
Jun 16, 2023 | Gaonkar RH et al.
IGG100 used for radiolabeling of CXCR4-targeting radioligands with [⁶⁸Ga]Gallium

NETs

Disturbing the Redox Balance Using Buthionine Sulfoximine Radiosensitized Somatostatin Receptor-2 Expressing Pre-Clinical Models to Peptide Receptor Radionuclide Therapy with ¹⁷⁷Lu-DOTATATE
Apr 17, 2023 | Delbart W et al.
Modular-Lab PharmTracer used for production of [¹⁷⁷Lu]-DOTATATE

Preclinical Evaluation of [^155/161Tb]Tb-Crown-TATE-A Novel SPECT Imaging Theranostic Agent Targeting Neuroendocrine Tumours
Apr 01, 2023 | Wharton L et al.
AR-2000 used for TLC imaging of [^155/161Tb]Tb-Crown-TATE

NEUROLOGY

Time course of neuroinflammation after human stroke – a pilot study using co-registered PET and MRI
May 16, 2023 | D’Anna L et al.
Modular-Lab used for preparation of [¹¹C]-PBR28

Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
May 04, 2023 | Banka V et al. 
Flow-Count used in HPLC analysis of [¹⁸F]SFB

PNEUMOLOGY

[⁶⁸Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography
May 30, 2023 | Bendova K et al.
IGG100 used for the preparation [⁶⁸Ga]-ORNB

Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc.
May 22, 2023 | Sung PS et al.
AR-2000 used for TLC analysis of ¹¹¹In-labeled compounds

Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS
Apr 27, 2023 | Mahida RY et al.
AR-2000 used for TLC analysis of [³H] labeled compounds

UROLOGY

A prospective head-to-head comparison of [⁶⁸Ga]Ga-P16-093 and [⁶⁸Ga]Ga-PSMA-11 PET/CT in patients with primary prostate cancer
May 26, 2023 | Wang G et al.
GalliaPharm^® used to prepare [⁶⁸Ga]-PSMA-11 and [⁶⁸Ga]-P16-093

⁶⁸Ga-PSMA PET/CT and Prostate Cancer Diagnosis: Which SUVmax Value?
May 03, 2023 | Pepe P et al.
Modular-Lab Pharmtracer used for preparation of ⁶⁸Ga-PSMA-11

Treatment of Prostate Cancer with CD46-targeted ²²⁵Ac Alpha Particle Radioimmunotherapy
May 01, 2023 | Bidkar AP et al.
AR-2000 used for TLC analysis of [²²⁵Ac]DOTA-YS5

OTHER / GENERAL

Optimized production, purification, and radiolabeling of the ²⁰³Pb/²¹²Pb theranostic pair for nuclear medicine
Jun 30, 2023 | McNeil BL et al.
AR-2000 used for TLC analysis of ²⁰³Pb/²¹²Pb elutes

Organelle interactions compartmentalize hepatic fatty acid trafficking and metabolism
Jun 19, 2023 | Najt CP et al. 
AR-2000 used for [¹⁴C]Carbon labeled compounds

Asymmetric rotaxanes as dual-modality supramolecular imaging agents for targeting cancer biomarkers
Jun 01, 2023 | d‘Orchymont F et al.
IGG100 used for the preparation [⁶⁸Ga]Gallium labeled dual-modality imaging agents

Optimization of ¹⁷⁷Lu-labelling of DOTA-TOC, PSMA-I&T and FAPI-46 for clinical application
May 26, 2023 | Cankaya A et al. 
[¹⁷⁷Lu]Lutetium and Modular-Lab eazy used to radiolabel DOTA-TOC, PSMA-I&T and FAPI-46

Visualizing Galectin-3 Binding Protein Expression with ImmunoPET
May 16, 2023 | Keinänen O et al.
AR-2000 used for TLC analysis of [⁸⁹Zr]Zirconium labeled compound

Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop
May 05, 2023 | Trapp S et al.
IGG100 used in analysis of cyclotron-produced [⁶⁸Ga]Gallium

Radiolabeling, Quality Control, and Cell Binding Studies of New ^99mTc-Labeled Bisphosphonates: 99mTc-Ibandronate Sodium
May 01, 2023 | Ekinci M et al. 
AR-2000 used for TLC analysis of [^99mTc]Tc-IBD

Synthesis and Evaluation of Fluorine-18-Labeled L-Rhamnose Derivatives
Apr 27, 2023 | Zhang X et al. 
Flow-Count used for HPLC analysis of [¹⁸F]-fluoro-L-rhamnose

Cyclotron production of ⁴³Sc and ^44gSc from enriched ⁴²CaO, ⁴³CaO, and ⁴⁴CaO targets
Apr 26, 2023 | Becker KV et al. 
GalliaPharm^® used to obtain [⁶⁸Ga]Gallium for comparison with ⁴³Sc and ^44gSc as PET candidates

Radiometallation and photo-triggered release of ready-to-inject radiopharmaceuticals from the solid phase
Apr 17, 2023 | Smilowicz D et al.
IGG100 used for radiolabelling with [⁶⁸Ga]Gallium

¹³¹I-Labeled Anti-HER2 Nanobody for Targeted Radionuclide Therapy of HER2-Positive Breast Cancer
Apr 08, 2023 | Zhao L et al.
Flow-Count used in HPLC analysis of [¹³¹I]-NM-02